Genetic distance

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For 'genetic distance' in the context of a genetic map, see: Centimorgan

Genetic distance is a measure of the dissimilarity of genetic material between different species or individuals of the same species. By comparing the percentage difference between the same genes or junk DNA of different species, a figure can be obtained, which is a measure of "genetic distance". Depending upon the difference, and correcting this for known rates of evolution, genetic distance can be used as a tool to construct cladograms showing the family tree of all living beings.

There are several different methods for defining genetic distance. One genetic distance measure is given by the formula D=−log(In). The quantity In is called the "genetic identity" or "genetic similarity", and defined as In=ΣI÷#loci, where I=(Σ Pix•Piy)÷[(ΣPix²)·( ΣPiy²)]½. Pix is the proportion of allele i in population X, Piy is the proportion of allele i in population Y.

For instance, the fact that the genetic distance of chimpanzees and human beings is only ~5% (about 95% of the base pairs are exactly shared between human and chimpanzee DNA), suggests that human beings and chimpanzees last had a common ancestor about 5 million years ago, and that chimpanzees and humans are more closely related than either of the two species are related to gorillas and orangutan (which diverged about 9 million years ago, and 12 million years ago, respectively).